Many trials, particularly those for treatments of psychiatric disorders or pain, involve the use of human raters. This article looks at how human raters can contribute to apparently high placebo response rates. Drawing on his substantial experience as a board certified psychiatrist conducting clinical trials, Dr. Modell shares examples from his research as well as suggestions for minimizing problems.
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Dr. Modell is a board-certified psychiatrist with 20 years of experience in clinical research, teaching, and patient care in academic medicine. He has over 10 years of experience in clinical drug development (proof of concept through market support), medical affairs, successful NDA filings, medical governance, drug safety, compliance, and management within the pharmaceutical and CRO industries.