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Download the Minimal Clinically Important Difference in Efficacy Trials of Analgesics White Paper

offer-whitepaper.jpgFor clinical trials of the efficacy of analgesics, it is necessary to determine the smallest change in a patient reported outcome (PRO) pain scale score that would be considered important by patients, i.e., the minimal clinically important difference (MCID). This white paper includes a discussion of the following: 

  • Definition of MCID 
  • Medthods to determine the MCID
  • Distribution-based methods for estimating MCID
  • Considerations for children